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In some instances, administration of an otic formulation or composition described herein lowers the ratio of C max to C min and provides a larger Area Under the Curve (AUC) with a prolonged PK profile based on the C min

Traditional concealer approaches provide temporary masking without addressing root causes, while intensive treatments like laser therapy or chemical peels carry risks in this delicate eye area

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Therefore, it needs to be reconstituted with bacteriostatic water before it can be administered to research subjects